Error in the article: "driving under the influence of opiates: concentration relationships between morphine, codeine, 6-acetyl morphine, and ethyl morphine in blood".

نویسندگان

  • I Papoutsis
  • S Athanaselis
چکیده

We read carefully the very interesting article by Jones et al. (1), which appears in the latest issue of the Journal. To our surprise, we realized that, during the determination of opiates in blood, although the described derivatization procedure involves BSTFA, the authors use, for their qualitative and quantitative analysis, mass fragments that correspond to their pentafluoroderivatives and the respective pentafluorodeuterated internal standards [m/z 414/417 (qualifier ions 361 and 577) for morphine, m/z 445/448 (qualifier ion 282) for codeine, m/z 414/417 (qualifying ions 361 and 473) for 6-AM, and m/z 459/448 (qualifier 296 and 430) for ethyl morphine]. Nevertheless, for the determination of 6-AM in urine, the correct mass-to-charge ratio of the 6-AM trimethylsilylester derivative was used (399/402). This mistake should be corrected as it is a significant flaw in an otherwise excellent article.

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منابع مشابه

Driving under the influence of opiates: concentration relationships between morphine, codeine, 6-acetyl morphine, and ethyl morphine in blood.

Morphine and codeine are frequently identified in blood samples from impaired drivers. But whether these opiates reflect the use of prescription analgesics or abuse of the illicit drug heroin (diacetyl morphine) is not always obvious. Opiates, either alone or together with other drugs, were determined in 2,573 blood specimens from impaired drivers by sensitive and specific methods of analysis. ...

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A practical approach to determine cutoff concentrations for opiate testing with simultaneous detection of codeine, morphine, and 6-acetylmorphine in urine.

BACKGROUND Both the Department of Defense (DoD) and the Department of Health and Human Services (DHHS) currently require two confirmation tests to verify use of heroin, one test for total morphine and a separate test for 6-acetylmorphine (6-AM). Our aim was to determine appropriate free-codeine, free-morphine, and 6-AM cutoff concentrations that could be substituted for total-morphine, total-co...

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عنوان ژورنال:
  • Journal of analytical toxicology

دوره 32 5  شماره 

صفحات  -

تاریخ انتشار 2008